Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580485 | 0.86 | LMNA (0.38) | KDM4EPKMADORA2AADORA1LMNA | |
| SCHEMBL3606506 | 0.77 | GOT1 (0.32) | — | |
| SCHEMBL580414 | 0.74 | MAPT (0.49) | KDM4EPKMLMNASMN1; SMN2HTT | |
| SCHEMBL29537275 | 0.74 | MAPT (0.49) | KDM4EPKMLMNASMN1; SMN2HTT | |
| SCHEMBL581638 | 0.72 | LMNA (0.37) | KDM4EADORA2AADORA1LMNAHTT | |
| SCHEMBL8551380 | 0.69 | LMNA (0.45) | KDM4EPKMADORA2AADORA1LMNA | |
| SCHEMBL28471578 | 0.68 | KDM4E (0.44) | KDM4EPKMADORA2AADORA1LMNA | |
| SCHEMBL7262166 | 0.68 | MAOA (0.45) | KDM4EPKMADORA2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9138181 | 0.67 | KDM4E (0.47) | KDM4EPKMADORA2AADORA1LMNA | |
| SCHEMBL1316871 | 0.67 | PTGS1 (0.41) | KDM4EPKMLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534443-B1 | 3,6-Disubstituted pyridazine derivatives | MITSUBISHI CHEM CORP (JP) | 1998-12-30 | — | — | EP | disclosed |
| US-5462941-A | 1-(cyclohexylalkylamino)-4-(phenyl, thienyl, or furyl) phthalazines; anti-platelet agglutination agents for treatment or prevention of cerebro- or cardiovascular disorders | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0534443-A1 | 3,6-Disubstituted pyridazine derivatives | Mitsubishi Chemical Corporation (JP) | 1993-03-31 | — | — | EP | disclosed |