Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 7/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553484 | 0.95 | HRH3 (0.47) | HRH3DRD2DRD3SIGMAR1 | |
| SCHEMBL8552527 | 0.94 | HRH3 (0.41) | HRH3DRD2DRD3SIGMAR1 | |
| SCHEMBL8551063 | 0.94 | HTR2A (0.41) | HRH3SIGMAR1 | |
| SCHEMBL8442979 | 0.88 | GSK3A (0.46) | SIGMAR1 | |
| SCHEMBL8440233 | 0.86 | FAAH (0.44) | SIGMAR1 | |
| SCHEMBL8438564 | 0.85 | GSK3A (0.43) | SIGMAR1 | |
| SCHEMBL8552347 | 0.84 | LTA4H (0.41) | — | |
| SCHEMBL8443375 | 0.82 | GAA (0.44) | HRH3 | |
| SCHEMBL8772537 | 0.81 | POLB (0.40) | SIGMAR1 | |
| SCHEMBL8439553 | 0.78 | NAAA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |