Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439355 | 0.86 | GSK3A (0.44) | ALDH1A1CYP2C19CYP2D6CYP1A2SMN1; SMN2 | |
| SCHEMBL8623161 | 0.84 | GSK3B (0.39) | ALDH1A1HSD17B10SMN1; SMN2KMT2ANAAA | |
| SCHEMBL8590402 | 0.83 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AMAPTLMNA | |
| SCHEMBL8772454 | 0.80 | POLB (0.42) | ALDH1A1KMT2ALMNA | |
| SCHEMBL8772449 | 0.80 | CYP1A2 (0.42) | ALDH1A1CYP2C19CYP2D6CYP1A2KMT2A | |
| SCHEMBL8550864 | 0.73 | HDAC1 (0.39) | HRH1RAB9AKMT2ALMNA | |
| SCHEMBL8442243 | 0.69 | TRPV1 (0.49) | ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL8772533 | 0.68 | KCNA5 (0.42) | ALDH1A1CYP2C19SMN1; SMN2KMT2AMAPT | |
| SCHEMBL12040591 | 0.68 | HRH1 (0.67) | HRH1ALDH1A1CYP2C19CYP2D6CYP1A2 | |
| SCHEMBL8440706 | 0.68 | HMOX1 (0.40) | ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865429-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021676-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-19 | — | — | WO | disclosed |