Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439355 | 0.93 | GSK3A (0.44) | GSK3BGSK3ASIGMAR1MEN1ALDH1A1 | |
| SCHEMBL8772449 | 0.86 | CYP1A2 (0.42) | GSK3BGSK3AMEN1ALDH1A1KMT2A | |
| SCHEMBL8772454 | 0.86 | POLB (0.42) | GSK3BGSK3ASIGMAR1MEN1ALDH1A1 | |
| SCHEMBL8552263 | 0.84 | HRH1 (0.39) | ALDH1A1KMT2ASMN1; SMN2HSD17B10NAAA | |
| SCHEMBL8549758 | 0.83 | TRPV1 (0.44) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8104154 | 0.78 | FAAH (0.44) | GSK3BGSK3ASIGMAR1MEN1KMT2A | |
| SCHEMBL8442243 | 0.75 | TRPV1 (0.49) | ALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8550864 | 0.75 | HDAC1 (0.39) | MEN1KMT2A | |
| SCHEMBL8619484 | 0.74 | GSK3B (0.39) | GSK3BGSK3ASIGMAR1MEN1KMT2A | |
| SCHEMBL8772533 | 0.74 | KCNA5 (0.42) | MEN1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865429-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021676-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-19 | — | — | WO | disclosed |