Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPFFR1 | Q9GZQ6 | 4/20 | 0.33 |
| ▸ | NPFFR2 | Q9Y5X5 | 4/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554034 | 0.82 | PLG (0.50) | PLAUPLG | |
| SCHEMBL8549276 | 0.82 | PLAU (0.43) | PLAUHSD11B1PLG | |
| SCHEMBL8372792 | 0.82 | PLAU (0.43) | PLAUPLGNPFFR1NPFFR2 | |
| Hydrochloric Acid SCHEMBL8551595 | 0.81 | PLAU (0.42) | PLAUPLGNPFFR1NPFFR2 | |
| SCHEMBL8374823 | 0.79 | PLAU (0.47) | PLAUPLG | |
| SCHEMBL8552267 | 0.78 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL8550323 | 0.78 | PLG (0.42) | PLAUPLG | |
| Hydrochloric Acid SCHEMBL8547382 | 0.78 | PLAU (0.46) | PLAUPLG | |
| SCHEMBL8548393 | 0.78 | HSD11B1 (0.44) | HSD11B1NOTUMPIK3R1PIK3CA | |
| Hydrochloric Acid SCHEMBL8548633 | 0.77 | PLG (0.41) | PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |