Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 13/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554476 | 0.85 | TSHR (0.46) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8554097 | 0.82 | ALDH1A1 (0.45) | TSHRALDH1A1SMN1; SMN2SIRT2SIRT1 | |
| SCHEMBL8605054 | 0.82 | TSHR (0.43) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8600794 | 0.82 | TP53 (0.38) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8603793 | 0.81 | ALDH1A1 (0.45) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8552323 | 0.81 | TSHR (0.41) | TSHRALDH1A1SMN1; SMN2SIRT2SIRT1 | |
| SCHEMBL8554310 | 0.81 | TSHR (0.48) | TSHRALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL8604584 | 0.80 | KDM4E (0.45) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8604513 | 0.78 | TSHR (0.44) | TSHRALDH1A1SMN1; SMN2TP53PPARG | |
| SCHEMBL8557727 | 0.77 | GSK3B (0.47) | TSHRALDH1A1SMN1; SMN2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |