SCHEMBL8552556

SCHEMBL8552556

Nc1ccc(Oc2cc(-c3c(F)c(F)c(F)c(F)c3F)c(F)c(F)c2F)c(C(F)(F)F)c1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.45
GLA P06280 1/20 0.45
POLB P06746 1/20 0.45
TSHR P16473 1/20 0.45
KIF11 P52732 1/20 0.33
NR1H2 P55055 1/20 0.33
AR P10275 2/20 0.30
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
SRC P12931 1/20 0.30
HPGD P15428 1/20 0.30
CASP1 P29466 1/20 0.30
CASP7 P55210 1/20 0.30
KMT2A Q03164 1/20 0.30
ATM Q13315 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
HSD17B10 Q99714 1/20 0.30
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28399265 0.81 GAA (0.42) GAAGLAPOLBTSHRKIF11
SCHEMBL29404322 0.81 GAA (0.59) GAAGLAPOLBTSHRKIF11
SCHEMBL436804 0.81 GAA (0.59) GAAGLAPOLBTSHRKIF11
Hydrochloric Acid SCHEMBL8863493 0.79 GAA (0.57) GAAGLAPOLBTSHRKIF11
SCHEMBL142021 0.79 POLB (0.46) GAAGLAPOLBTSHRKIF11
SCHEMBL30638537 0.77 GAA (0.41) GAAGLAPOLBTSHRKIF11
SCHEMBL6281871 0.77 POLB (0.50) GAAGLAPOLBTSHRKIF11
SCHEMBL30223697 0.77 GAA (0.50) GAAGLAPOLBTSHRKIF11
SCHEMBL3137458 0.75 ALDH1A1 (0.43) GAAPOLBTSHRKDM4EMEN1
SCHEMBL649658 0.75 TSHR (0.52) GAAGLAPOLBTSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5783656-A REACTING AN AROMATIC DIAMINE WITH A TETRACARBOXYLIC DIANHYDRIDE JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-07-21 US disclosed
US-5773559-A POLYAMIC ACID, POLYIMIDE BLOCK POLYMERS JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-06-30 US disclosed
US-5756649-A HAVING THE ABILITY TO CHANGE THE PRETILT ANGLE WITH RADIATION JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1998-05-26 US disclosed
US-5700860-A Liquid crystal orienting agent JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1997-12-23 US disclosed