Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 11/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 8/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547499 | 0.90 | HTR1D (0.46) | RAB9ATMIGD3ADORA1DRD2SLC6A4 | |
| SCHEMBL8553184 | 0.88 | RAB9A (0.41) | RAB9ATMIGD3ADORA1DRD2SLC6A4 | |
| SCHEMBL8552303 | 0.87 | RAB9A (0.43) | RAB9ATMIGD3ADORA1HTR1DMAPK14 | |
| SCHEMBL8550584 | 0.87 | RAB9A (0.41) | RAB9ATMIGD3ADORA1DRD2HTR1D | |
| SCHEMBL8552316 | 0.83 | NPC1 (0.54) | RAB9ADRD2SLC6A4 | |
| SCHEMBL8721836 | 0.82 | TMIGD3 (0.41) | RAB9ATMIGD3ADORA1DRD2HTR1D | |
| SCHEMBL7479333 | 0.81 | HTR1D (0.62) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8547605 | 0.77 | RORC (0.45) | DRD2SLC6A4HTR1DHTR1BHTR1A | |
| Phosphoric Acid SCHEMBL7866432 | 0.76 | DRD2 (0.44) | DRD2SLC6A4HTR1DHTR1BHTR1A | |
| SCHEMBL8549540 | 0.75 | HTR1D (0.48) | DRD2SLC6A4HTR1DMAPK14HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |