Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 11/20 | 0.38 |
| ▸ | HTR1B | P28222 | 8/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1F | P30939 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552303 | 0.90 | RAB9A (0.43) | RAB9ATMIGD3ADORA1MAPK14HSPB1 | |
| SCHEMBL8552643 | 0.88 | RAB9A (0.41) | RAB9ATMIGD3ADORA1MAPK14HSPB1 | |
| SCHEMBL8550584 | 0.85 | RAB9A (0.41) | RAB9ATMIGD3ADORA1MAPK14HSPB1 | |
| SCHEMBL8547499 | 0.84 | HTR1D (0.46) | RAB9ATMIGD3ADORA1MAPK14HSPB1 | |
| SCHEMBL8553071 | 0.84 | KMT2A (0.47) | RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL7485124 | 0.82 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| SCHEMBL30909189 | 0.82 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| SCHEMBL8552293 | 0.82 | LMNA (0.42) | HTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL8548010 | 0.82 | DRD2 (0.40) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| SCHEMBL8704365 | 0.81 | DRD2 (0.42) | RAB9AHTR1DHTR1BDRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |