Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 5/20 | 0.66 |
| ▸ | CES1 | P23141 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552682 | 0.86 | CES2 (0.66) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL6473958 | 0.84 | MAPT (0.48) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL7170746 | 0.83 | ALDH1A1 (0.60) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL11281139 | 0.83 | CES2 (0.67) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL2528895 | 0.82 | LMNA (0.67) | CES2CES1ALDH1A1LMNAKDM4E | |
| SCHEMBL18438933 | 0.82 | CES2 (0.84) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL11279590 | 0.80 | CES2 (0.66) | CES2CES1ALDH1A1LMNAKDM4E | |
| SCHEMBL11382156 | 0.80 | CES2 (1.00) | CES2CES1ALDH1A1LMNAGAA | |
| SCHEMBL68736 | 0.80 | CES2 (0.55) | CES2CES1ALDH1A1LMNAKDM4E | |
| SCHEMBL6203136 | 0.78 | GABBR2 (0.62) | CES2CES1ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |