Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551133 | 0.89 | NR1H2 (0.42) | MAPTENPP1ESR1 | |
| SCHEMBL8546259 | 0.88 | NR1H2 (0.41) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8550781 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8547668 | 0.78 | PLAU (0.37) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8547661 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8551333 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL8548542 | 0.75 | ROCK2 (0.47) | ALDH1A1SMN1; SMN2MAPTNPSR1LMNA | |
| SCHEMBL7904780 | 0.75 | ALDH1A1 (0.60) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 | |
| SCHEMBL26614999 | 0.74 | KDM4E (0.39) | SMN1; SMN2NPSR1KDM4ETRPV1ENPP1 | |
| SCHEMBL8548608 | 0.74 | MAPT (0.44) | ALDH1A1HTTSMN1; SMN2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |