Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552718 | 0.89 | ALDH1A1 (0.42) | ESR1MAPTENPP1 | |
| SCHEMBL8546259 | 0.88 | NR1H2 (0.41) | NR1H2NR1H3ADORA2AADORA1ESR1 | |
| SCHEMBL8547763 | 0.79 | ADORA2A (0.38) | ADORA2AADORA1ESR1MAPT | |
| SCHEMBL8551877 | 0.79 | ESR1 (0.37) | ADORA2AADORA1ESR1MAPT | |
| SCHEMBL26614999 | 0.77 | KDM4E (0.39) | NR1H2NR1H3ENPP1 | |
| SCHEMBL8553715 | 0.77 | NR1H2 (0.38) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1268020 | 0.75 | ESR1 (0.49) | ADORA2AESR1MAPT | |
| SCHEMBL8553708 | 0.75 | LMNA (0.35) | NR1H2NR1H3NR1I2NR3C1ADORA2A | |
| SCHEMBL8551845 | 0.73 | ROCK2 (0.48) | NR1H2NR1H3ARP2RX7MAPT | |
| SCHEMBL1407266 | 0.72 | SMN1; SMN2 (0.50) | NR1H2NR1H3NR1I2NR3C1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |