Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 6/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809869 | 0.93 | HRH3 (0.34) | ASAH1CASP6ALDH1A1LMNAMEN1 | |
| SCHEMBL8595503 | 0.89 | POLB (0.39) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL27494322 | 0.89 | LMNA (0.39) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8592460 | 0.87 | ASAH1 (0.37) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8442258 | 0.86 | TDP1 (0.34) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8552851 | 0.84 | PLA2G7 (0.39) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8104153 | 0.83 | EPHX2 (0.35) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8517608 | 0.81 | LMNA (0.35) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL8809251 | 0.81 | MEN1 (0.39) | PLA2G7ASAH1NAMPTALDH1A1KDM4E | |
| SCHEMBL8443653 | 0.79 | KMT2A (0.46) | ASAH1ALDH1A1KDM4ETDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |