SCHEMBL855290

SCHEMBL855290

O=C1OC(=O)c2c(Cl)c(Cl)cc(Cl)c21

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.56
ALDH1A1 P00352 3/20 0.56
CYP3A4 P08684 1/20 0.39
AHR P35869 8/20 0.38
HPGD P15428 3/20 0.35
HSD17B10 Q99714 3/20 0.35
CASP1 P29466 1/20 0.35
MEN1 O00255 1/20 0.34
HSP90AA1 P07900 1/20 0.34
KMT2A Q03164 1/20 0.34
MAPK1 P28482 1/20 0.32
TYMS P04818 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855163 0.80 ALDH1A1 (0.50) TSHRALDH1A1AHRMEN1HSP90AA1
SCHEMBL13991795 0.80 TSHR (0.50) TSHRALDH1A1CYP3A4AHR
SCHEMBL4939317 0.77 ALDH1A1 (0.46) TSHRALDH1A1MEN1KMT2A
SCHEMBL2884593 0.76 ALDH1A1 (0.45) TSHRALDH1A1CYP3A4HPGDHSD17B10
SCHEMBL542 0.74 TSHR (0.52) TSHRALDH1A1AHRTYMS
SCHEMBL29555800 0.74 TSHR (0.52) TSHRALDH1A1AHRTYMS
SCHEMBL21861 0.73 TSHR (1.00) TSHRALDH1A1AHRHSD17B10
SCHEMBL30354042 0.73 TSHR (1.00) TSHRALDH1A1AHRHSD17B10
SCHEMBL855562 0.73 ALDH1A1 (0.52) TSHRALDH1A1CYP3A4AHRMEN1
Water SCHEMBL28019026 0.71 TSHR (0.94) TSHRALDH1A1AHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230323137-A1 COMPOSITION FOR SEALING COATED ELECTRIC WIRE, AND COATED ELECTRIC WIRE TOAGOSEI CO. LTD. (JP) 2023-10-12 US disclosed
EP-3260509-B1 2-CYANOACRYLATE ADHESIVE COMPOSITION TOAGOSEI CO LTD (JP) 2021-04-07 EP disclosed
WO-2021060390-A1 COMPOSITION FOR COVERED-WIRE SEAL AND COVERED WIRE 東亞合成株式会社 2021-04-01 WO disclosed
CN-107250302-B 2-cyanoacrylate-based adhesive composition 东亚合成株式会社 2021-02-26 CN disclosed
US-10647888-B2 2-cyanoacrylate adhesive composition TOAGOSEI CO., LTD. (JP) 2020-05-12 US disclosed
EP-2433933-B1 PRODUCTION METHOD OF TRI- OR TETRAHALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL CO (JP) 2019-05-08 EP disclosed
US-20180037772-A1 2-CYANOACRYLATE ADHESIVE COMPOSITION TOAGOSEI CO., LTD. (JP) 2018-02-08 US disclosed
EP-3260509-A1 2-CYANOACRYLATE ADHESIVE COMPOSITION Toagosei Co., Ltd. (JP) 2017-12-27 EP disclosed
CN-105849094-A Method for producing halogen-substituted phthalide 住友化学株式会社 2016-08-10 CN disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
EP-0569620-A1 Method of making 2,4,5-trihalobenzoic acid OCCIDENTAL CHEMICAL CORPORATION (US) 1993-11-18 EP disclosed
US-5196590-A Heating a trihalophthalimide compound, water, mineral acid OCCIDENTAL CHEMICAL CORPORATION (US) 1993-03-23 US disclosed
EP-0525066-A4 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID 1993-03-17 EP disclosed
EP-0525066-A1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID. OCCIDENTAL CHEM CO (US) 1993-02-03 EP disclosed
EP-0495426-A2 Preparation of 3,5-dichlorophthalic acid and 3,5-dichlorophthalic anhydride OCCIDENTAL CHEMICAL CORPORATION (US) 1992-07-22 EP disclosed
US-5086188-A Preparation of 3,5-dichlorophthalic acid and 3,5-dichlorophthalic anhydride OCCIDENTAL CHEMICAL CORPORATION (US) 1992-02-04 US disclosed
WO-1991016308-A1 PREPARATION OF 3,4,6-TRIFLUOROPHTHALIC ACID OCCIDENTAL CHEMICAL CORPORATION (US) 1991-10-31 WO disclosed
US-5047553-A Tetrafluoro-N-phenylphthalimide OCCIDENTAL CHEMICAL CORPORATION (US) 1991-09-10 US disclosed
US-4515964-A Polyhalophthalimidoalkyl-functional carbonates PPG INDUSTRIES, INC. (US) 1985-05-07 US disclosed
US-4414396-A FIREPROOFING PPG INDUSTRIES, INC. (US) 1983-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10647888-B2 2-cyanoacrylate adhesive composition COL2A1, COL14A1, ICAM1 TSHR 4872/4885ALDH1A1 288/4885CYP3A4 4529/4885
US-20180037772-A1 2-CYANOACRYLATE ADHESIVE COMPOSITION COL2A1, COL14A1, ICAM1 TSHR 4872/4885ALDH1A1 288/4885CYP3A4 4529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.