SCHEMBL8551381

SCHEMBL8551381

OCCN(CCO)CCOc1ccc2nc(Cc3ccc(C(F)(F)F)cc3)sc2c1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 5/20 0.45
CACNA1H O95180 1/20 0.45
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
MAPT P10636 2/20 0.43
PPARG P37231 1/20 0.41
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41
CA1 P00915 4/20 0.40
CA2 P00918 4/20 0.40
CA4 P22748 1/20 0.40
CSNK1D P48730 1/20 0.38
ATP4A P20648 2/20 0.37
ATP4B P51164 2/20 0.37
AURKB Q96GD4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8551252 0.94 LMNA (0.50) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8551665 0.90 CACNA1B (0.47) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8359111 0.87 CACNA1B (0.53) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8516569 0.85 MAPT (0.44) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8552900 0.83 LMNA (0.53) CACNA1BLMNACYP1A2CYP2D6MAPT
SCHEMBL8359567 0.82 AURKB (0.45) LMNACYP1A2CYP2D6MAPTPPARD
SCHEMBL8554328 0.82 LMNA (0.48) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8361490 0.81 LMNA (0.53) LMNACYP1A2CYP2D6MAPTPPARD
SCHEMBL8550957 0.81 CACNA1B (0.44) CACNA1BCACNA1HLMNACYP1A2CYP2D6
SCHEMBL8358041 0.81 KMT2A (0.52) LMNACYP1A2CYP2D6MAPTPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824529-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-02-25 EP claimed
WO-1996035681-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-11-14 WO claimed
EP-0824529-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-02-25 EP disclosed
WO-1996035681-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-11-14 WO disclosed