Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 9/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.43 |
| ▸ | PTGIR | P43119 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555638 | 0.87 | SUCNR1 (0.43) | FYNLMNAKMT2A | |
| SCHEMBL8118375 | 0.86 | KCNA5 (0.49) | FYNCYP3A4PIP4K2APIP4K2B | |
| SCHEMBL8554677 | 0.84 | EPHX1 (0.42) | LMNAPKM | |
| SCHEMBL8551743 | 0.83 | KMO (0.51) | LMNA | |
| SCHEMBL8552459 | 0.83 | CYP17A1 (0.44) | CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8552624 | 0.82 | CYP19A1 (0.47) | CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8109544 | 0.82 | SMN1; SMN2 (0.44) | CYP17A1CYP3A4PKM | |
| SCHEMBL8118468 | 0.82 | KCNA5 (0.45) | CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8118689 | 0.82 | KCNA5 (0.48) | CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8118264 | 0.82 | DGAT2 (0.39) | CYP17A1CYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |