Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547084 | 0.80 | PLAU (0.51) | PLAUPLGADORA2AADORA1F9 | |
| SCHEMBL8552255 | 0.78 | ADORA2A (0.44) | HSP90AA1ADORA2AADORA1CCR1CCR5 | |
| SCHEMBL8552963 | 0.75 | ADORA2A (0.39) | SLC2A1ADORA3ADORA2AADORA1CCR1 | |
| SCHEMBL8548298 | 0.72 | PLAU (0.40) | PLAUADORA3PLGADORA2AADORA1 | |
| SCHEMBL8553148 | 0.71 | PLAU (0.42) | PLAUSLC2A1ADORA3PLGHSP90AA1 | |
| SCHEMBL9807627 | 0.66 | METAP1 (0.47) | HSP90AA1ADORA2AADORA1CCR1CCR5 | |
| SCHEMBL8549645 | 0.65 | LRRK2 (0.53) | CCR1CCR5CCR8NPSR1 | |
| SCHEMBL7952022 | 0.65 | KDM4E (0.70) | HSP90AA1ADORA2AADORA1CCR1CCR5 | |
| SCHEMBL8551931 | 0.64 | PLG (0.53) | PLAUPLGNPSR1 | |
| SCHEMBL9775492 | 0.63 | KDM4E (0.56) | HSP90AA1ADORA2AADORA1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |