SCHEMBL8553264

SCHEMBL8553264

CCCCCCC1Cc2ccc(-c3ccc(N)cn3)cc2C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.38
CYP2C8 P10632 2/20 0.38
S1PR3 Q99500 2/20 0.38
RAB9A P51151 5/20 0.38
GRIA2 P42262 4/20 0.38
KDM4E B2RXH2 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
MAPT P10636 3/20 0.38
ALDH1A1 P00352 3/20 0.38
HPGD P15428 3/20 0.38
HSD17B10 Q99714 2/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
GAA P10253 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
FLT3 P36888 1/20 0.37
TYRO3 Q06418 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8556271 0.86 NPC1 (0.47) CYP3A4CYP2C8S1PR3RAB9AGRIA2
SCHEMBL8553142 0.85 RAB9A (0.55) CYP3A4CYP2C8S1PR3RAB9AKDM4E
SCHEMBL8552877 0.84 KDM4E (0.48) CYP3A4RAB9AGRIA2KDM4EMAPT
SCHEMBL8556156 0.83 CYP3A4 (0.40) CYP3A4CYP2C8S1PR3GRIA2MAPT
SCHEMBL8552673 0.83 CYP3A4 (0.40) CYP3A4CYP2C8S1PR3GRIA2MAPT
SCHEMBL8555744 0.83 HPGDS (0.43) CYP3A4CYP2C8S1PR3RAB9AGRIA2
SCHEMBL8552658 0.83 KDM4E (0.56) CYP3A4CYP2C8S1PR3RAB9AGRIA2
SCHEMBL8554697 0.81 NPC1 (0.40) RAB9AGRIA2SMN1; SMN2MAPTNPC1
SCHEMBL8555083 0.80 NPC1 (0.40) CYP3A4CYP2C8S1PR3RAB9AGRIA2
SCHEMBL8552620 0.76 CYP3A4 (0.38) CYP3A4CYP2C8S1PR3RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0546338-B1 Mesomorphic compound, liquid crystal composition, liquid crystal device, display apparatus and display method CANON KK (JP) 1998-02-04 EP disclosed
US-5385692-A Improved response CANON KABUSHIKI KAISHA (JP) 1995-01-31 US disclosed
EP-0546338-A1 Mesomorphic compound, liquid crystal composition, liquid crystal device, display apparatus and display method CANON KABUSHIKI KAISHA (JP) 1993-06-16 EP disclosed