Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 6/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 4/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553560 | 0.87 | DRD2 (0.37) | MAPTMEN1USP2KMT2ADRD2 | |
| SCHEMBL7483905 | 0.84 | HTR1D (0.50) | DRD2 | |
| SCHEMBL8552230 | 0.84 | DRD2 (0.41) | DRD2 | |
| SCHEMBL8548010 | 0.81 | DRD2 (0.40) | MAPTMEN1USP2KMT2ADRD2 | |
| SCHEMBL8552547 | 0.78 | DRD2 (0.47) | MAPTMEN1USP2KMT2ADRD2 | |
| SCHEMBL8552124 | 0.76 | DRD2 (0.43) | MAPTMEN1USP2KMT2ADRD2 | |
| SCHEMBL8548444 | 0.75 | ALDH1A1 (0.39) | DRD2SLC6A4TRPV4RORCALDH1A1 | |
| SCHEMBL8547967 | 0.75 | MAPT (0.46) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8552303 | 0.74 | RAB9A (0.43) | RORC | |
| SCHEMBL8704365 | 0.74 | DRD2 (0.42) | MAPTMEN1KMT2ADRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |