Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704365 | 0.86 | DRD2 (0.42) | DRD2SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL8548023 | 0.84 | DRD2 (0.50) | DRD2SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL8553071 | 0.84 | KMT2A (0.47) | MAPTMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL8552293 | 0.84 | LMNA (0.42) | DRD2SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL8553184 | 0.82 | RAB9A (0.41) | DRD2SLC6A4RORCHTR1DHTR1B | |
| SCHEMBL30908885 | 0.82 | HTR1D (0.56) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7483399 | 0.82 | HTR1D (0.56) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8553565 | 0.81 | MAPT (0.36) | DRD2SLC6A4MAOBMAPTMEN1 | |
| SCHEMBL8721187 | 0.80 | TDP1 (0.38) | MAOBMAPTMEN1KMT2AUSP2 | |
| SCHEMBL30909070 | 0.80 | TDP1 (0.38) | MAOBMAPTMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |