Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481923 | 0.82 | HTR1D (0.55) | DRD2HTR1AHTR1D | |
| SCHEMBL8550761 | 0.81 | DRD2 (0.45) | DRD2SLC6A4CHRM4MAPTKDM4E | |
| SCHEMBL8704937 | 0.81 | DRD2 (0.44) | DRD2SLC6A4NPY5RCHRM4MAPT | |
| SCHEMBL8547871 | 0.81 | HTR1D (0.43) | DRD2MAPTKDM4EALDH1A1RAB9A | |
| SCHEMBL8552657 | 0.79 | L3MBTL1 (0.49) | MAPTMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL8548023 | 0.79 | DRD2 (0.50) | DRD2SLC6A4MAPTMEN1KMT2A | |
| SCHEMBL8550058 | 0.79 | DRD2 (0.41) | DRD2SLC6A4NPY5RCHRM4HTR1A | |
| SCHEMBL8548010 | 0.79 | DRD2 (0.40) | DRD2SLC6A4CHRM4MAOBMAPT | |
| SCHEMBL8553277 | 0.78 | DRD2 (0.49) | DRD2SLC6A4F2RKMT2AKDM4E | |
| SCHEMBL8552510 | 0.78 | DRD2 (0.40) | DRD2SLC6A4NPY5RCHRM4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |