Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547804 | 0.82 | NPC1 (0.41) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8553027 | 0.80 | NPC1 (0.40) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL8548549 | 0.74 | HTR1F (0.50) | ROCK1SIGMAR1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21963739 | 0.72 | KMT2A (0.49) | ACHETSHRUSP2NPSR1SIGMAR1 | |
| SCHEMBL7599299 | 0.71 | CARM1 (0.59) | CARM1PRMT6PRMT8ROCK1SIGMAR1 | |
| SCHEMBL3148258 | 0.71 | CARM1 (0.59) | CARM1PRMT6PRMT8ROCK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6963204 | 0.70 | MAOB (0.60) | CARM1PRMT6PRMT8ROCK1SIGMAR1 | |
| SCHEMBL8402960 | 0.67 | SIGMAR1 (0.71) | CARM1PRMT6PRMT8TSHRUSP2 | |
| SCHEMBL20869695 | 0.66 | SIGMAR1 (0.53) | ACHECARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL3152066 | 0.65 | CARM1 (0.59) | ACHECARM1PRMT6PRMT8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |