Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.59 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.59 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148258 | 1.00 | CARM1 (0.59) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| Hydrochloric Acid SCHEMBL6963204 | 0.98 | MAOB (0.60) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL8402960 | 0.89 | SIGMAR1 (0.71) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL3152066 | 0.87 | CARM1 (0.59) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL21231364 | 0.85 | ALDH1A1 (0.65) | CARM1PRMT6PRMT8SIGMAR1ROCK1 | |
| SCHEMBL6538284 | 0.85 | SIGMAR1 (0.67) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL13222367 | 0.84 | KDM4E (0.62) | CARM1PRMT6PRMT8SIGMAR1ROCK1 | |
| SCHEMBL16980535 | 0.83 | SIGMAR1 (0.56) | CARM1PRMT6PRMT8SIGMAR1ROCK1 | |
| SCHEMBL3152104 | 0.83 | KDM4E (0.58) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL9627913 | 0.82 | SIGMAR1 (0.66) | SIGMAR1MAOBMAOAAOC3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | DUKE UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2022-01-25 | — | — | US | disclosed |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2021-05-25 | — | — | US | disclosed |
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2019-10-17 | — | — | US | disclosed |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY | 2019-03-28 | — | — | US | disclosed |
| WO-2017177200-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2016028325-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY (US) | 2016-02-25 | — | — | WO | disclosed |
| EP-0782567-B2 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| EP-0782567-B1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AB (SE) | 1999-06-30 | — | — | EP | disclosed |
| US-5721247-A | Isothiourea derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1998-02-24 | — | — | US | disclosed |
| EP-0782567-A1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | Astra Aktiebolag (SE) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009286-A1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1996-03-28 | — | — | WO | disclosed |
| WO-1994003425-A2 | CARBOSTYRIL DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIA | SYNTEX (U.S.A.) INC. (US) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | TRPA1, TRPV4, TRPV1 | CARM1 3080/4885PRMT6 3643/4885PRMT8 3127/4885 |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | TRPA1, TRPV4, TRPV1 | CARM1 3080/4885PRMT6 3643/4885PRMT8 3127/4885 |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | CARM1 4790/4885PRMT6 4763/4885PRMT8 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.