Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772451 | 0.76 | LMNA (0.40) | KMT2AMEN1LMNAPKML3MBTL1 | |
| SCHEMBL10415272 | 0.76 | ALDH1A1 (0.47) | KMT2AMEN1LMNAL3MBTL1HTT | |
| SCHEMBL8772395 | 0.75 | LMNA (0.39) | KMT2AMEN1LMNASLC6A4SLC6A3 | |
| SCHEMBL4466281 | 0.74 | FFAR1 (0.53) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8766432 | 0.73 | HTT (0.40) | KMT2AMEN1LMNAL3MBTL1HTT | |
| SCHEMBL9708647 | 0.73 | ALDH1A1 (0.51) | SLC6A2KMT2AMEN1LMNASLC6A3 | |
| SCHEMBL8766856 | 0.72 | HTT (0.39) | KMT2AMEN1LMNAHTTPOLB | |
| SCHEMBL8552278 | 0.72 | HMOX1 (0.48) | LMNAL3MBTL1HTT | |
| SCHEMBL8766787 | 0.72 | HTT (0.39) | KMT2AMEN1LMNAHTTCYP2C9 | |
| SCHEMBL6631553 | 0.71 | ALDH1A1 (0.49) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | claimed |