Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23871985 | 0.81 | SMN1; SMN2 (0.50) | HMOX1TDP1NPC1KEAP1HTT | |
| SCHEMBL10415272 | 0.77 | ALDH1A1 (0.47) | NPC1HTTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL11513541 | 0.76 | NPC1 (0.58) | TDP1NPC1HTTL3MBTL1GAA | |
| SCHEMBL4404820 | 0.74 | NPC1 (0.58) | TDP1NPC1KEAP1FKBP1ALMNA | |
| SCHEMBL9708647 | 0.74 | ALDH1A1 (0.51) | TDP1NPC1HTTLMNAALDH1A1 | |
| SCHEMBL497371 | 0.73 | KEAP1 (0.73) | TDP1NPC1KEAP1HTTALDH1A1 | |
| SCHEMBL7389188 | 0.72 | L3MBTL1 (0.73) | NPC1L3MBTL1GAA | |
| SCHEMBL7695918 | 0.72 | FKBP1A (0.63) | HTTFKBP1ALMNAALDH1A1GAA | |
| SCHEMBL8772451 | 0.72 | LMNA (0.40) | HTTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL8553752 | 0.72 | CACNA2D1 (0.40) | HTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | claimed |