Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772395 | 0.85 | LMNA (0.39) | HTTLMNAALDH1A1ADRA1DADRA1A | |
| SCHEMBL8767413 | 0.84 | PKM (0.37) | HTTLMNAALDH1A1ADRA1DADRA1A | |
| SCHEMBL8767579 | 0.82 | PKM (0.40) | HTTLMNAADRA1DADRA1AADRA1B | |
| SCHEMBL8766432 | 0.77 | HTT (0.40) | HTTLMNAALDH1A1ADRA1DADRA1A | |
| SCHEMBL8767549 | 0.77 | LMNA (0.39) | LMNA | |
| SCHEMBL8766856 | 0.76 | HTT (0.39) | HTTLMNAALDH1A1ADRA1DADRA1A | |
| SCHEMBL8766792 | 0.75 | TRPA1 (0.40) | LMNA | |
| SCHEMBL8772451 | 0.72 | LMNA (0.40) | HTTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8553752 | 0.72 | CACNA2D1 (0.40) | HTTLMNAADRA1DADRA1AADRA1B | |
| SCHEMBL8767339 | 0.71 | HTT (0.38) | HTTLMNAALDH1A1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |