SCHEMBL8553833

SCHEMBL8553833

C=CC(N)Oc1ccccc1O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
CA2 P00918 2/20 0.42
TP53 P04637 2/20 0.42
CA1 P00915 1/20 0.42
MAPT P10636 4/20 0.39
GAA P10253 3/20 0.39
LMNA P02545 3/20 0.39
JAK2 O60674 1/20 0.39
HPGD P15428 4/20 0.33
KDM4E B2RXH2 3/20 0.33
ALOX15 P16050 3/20 0.33
HSD17B10 Q99714 3/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
ALDH1A1 P00352 2/20 0.33
CYP3A4 P08684 2/20 0.33
CA12 O43570 1/20 0.33
GMNN O75496 1/20 0.33
EGFR P00533 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11447956 0.77 ALDH1A1 (0.38) TSHRHPGDHSD17B10ALDH1A1CYP3A4
SCHEMBL11305268 0.77 TP53 (0.47) TSHRCA2TP53CA1MAPT
SCHEMBL3232712 0.75 KDM4E (0.49) TSHRMAPTLMNAHPGDKDM4E
SCHEMBL11124897 0.74 HTR1B (0.43) HPGDKDM4ETDP1ALDH1A1
SCHEMBL9507359 0.74 LMNA (0.42) TSHRGAALMNAHPGDALDH1A1
SCHEMBL19973199 0.74 TSHR (0.52) TSHRCA2TP53CA1MAPT
SCHEMBL11377035 0.72 SLC6A3 (0.49) TSHRCA2CA1MAPTGAA
SCHEMBL527140 0.71 SCN4A (0.36) TSHRCA2CA1KDM4EALDH1A1
SCHEMBL9427353 0.70 CA2 (0.52) TSHRCA2TP53CA1MAPT
SCHEMBL7938292 0.69 CA1 (0.35) TSHRCA2TP53CA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5874436-A EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS DEMERS JAMES P (US) 1999-02-23 US disclosed
US-5773469-A Diaryl antimicrobial agents ORTHO PHARMACEUTICAL CORPORATION (US) 1998-06-30 US disclosed
WO-1997048676-A1 TRIPHENYLALKYL ANTIMICROBIAL AGENTS ORTHO PHARMACEUTICAL CORPORATION (US) 1997-12-24 WO disclosed
WO-1997048674-A1 DIARYL ANTIMICROBIAL AGENTS ORTHO PHARMACEUTICAL CORPORATION (US) 1997-12-24 WO disclosed
US-5643950-A INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE ORTHO PHARMACEUTICAL CORPORATION (US) 1997-07-01 US disclosed