Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 1/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554540 | 1.00 | SHMT1 (0.50) | SHMT1SHMT2P2RX7KDM4EALDH1A1 | |
| SCHEMBL8555896 | 0.86 | MEN1 (0.55) | P2RX7ALDH1A1TSHRHDAC3HDAC1 | |
| SCHEMBL8654991 | 0.86 | MEN1 (0.55) | P2RX7ALDH1A1TSHRHDAC3HDAC1 | |
| SCHEMBL8558522 | 0.86 | SDCBP (0.53) | P2RX7ALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL8558519 | 0.86 | SDCBP (0.53) | P2RX7ALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL8557039 | 0.85 | MAPK1 (0.55) | P2RX7KDM4EALDH1A1 | |
| SCHEMBL8557036 | 0.85 | MAPK1 (0.55) | P2RX7KDM4EALDH1A1 | |
| SCHEMBL8558467 | 0.83 | FPR2 (0.44) | P2RX7KDM4EALDH1A1TSHR | |
| SCHEMBL8558470 | 0.83 | FPR2 (0.44) | P2RX7KDM4EALDH1A1TSHR | |
| SCHEMBL4422717 | 0.82 | LPAR1 (0.50) | SHMT1SHMT2KDM4EALDH1A1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847211-A | Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| US-5622917-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |