Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.35 |
| ▸ | FEN1 | P39748 | 5/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557001 | 0.92 | RXRA (0.40) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8555605 | 0.91 | RXRA (0.44) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8559710 | 0.90 | PTGS2 (0.42) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8557473 | 0.89 | NR4A2 (0.44) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8554948 | 0.87 | PTGS2 (0.42) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8558000 | 0.87 | RXRA (0.47) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8556041 | 0.87 | RXRA (0.47) | RXRARXRBRXRGNR4A2FAAH | |
| SCHEMBL8558565 | 0.87 | PTGS2 (0.44) | RXRARXRBRXRGPTGS1PTGS2 | |
| SCHEMBL8556639 | 0.85 | FAAH (0.36) | ALOX5APFEN1NR4A2PTGES2FAAH | |
| SCHEMBL8561143 | 0.85 | POLB (0.37) | PTGS1PTGS2ALOX5APFEN1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |