Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.41 |
| ▸ | FEN1 | P39748 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559238 | 0.92 | PTGS2 (0.42) | PTGS2PTGS1ALOX5APFEN1TP53 | |
| SCHEMBL8557215 | 0.92 | PTGS2 (0.42) | PTGS2PTGS1ALOX5APFEN1TP53 | |
| SCHEMBL8558256 | 0.91 | MAOB (0.41) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8554948 | 0.91 | PTGS2 (0.42) | PTGS2PTGS1ALOX5APFEN1MAOB | |
| SCHEMBL8559701 | 0.88 | RXRA (0.39) | PTGS2PTGS1MAPTMAOBRXRA | |
| SCHEMBL8560736 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8557001 | 0.87 | RXRA (0.40) | PTGS2PTGS1ALOX5APFEN1MAOB | |
| SCHEMBL8555554 | 0.87 | RXRA (0.47) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8560020 | 0.86 | RXRA (0.39) | PTGS2PTGS1MAPTMAOBRXRA | |
| SCHEMBL7503580 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1TP53MAPTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |