Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 16/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 16/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 16/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 16/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560220 | 0.73 | F2 (0.47) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL31584278 | 0.72 | TRPV4 (0.40) | — | |
| SCHEMBL23140985 | 0.72 | TRPV4 (0.40) | — | |
| SCHEMBL8555843 | 0.71 | CA1 (0.32) | F2PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL8558200 | 0.69 | F2 (0.49) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL10515229 | 0.68 | F2 (0.59) | F2PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL29799541 | 0.63 | NNMT (0.61) | LMNA | |
| SCHEMBL384113 | 0.63 | NNMT (0.61) | LMNA | |
| SCHEMBL8559284 | 0.62 | CA1 (0.52) | LMNA | |
| SCHEMBL23833649 | 0.61 | PDIA6 (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |