Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | RPS27 | P42677 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098023 | 0.75 | NSD2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL7844395 | 0.73 | ADORA2A (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL8098030 | 0.72 | ADORA2A (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL7843220 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL7844391 | 0.69 | CREBBP (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL8090721 | 0.68 | KMT2A (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL7836007 | 0.65 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4MAPK10 | |
| SCHEMBL7844879 | 0.64 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4HPGD | |
| SCHEMBL28357196 | 0.64 | SGMS2 (0.76) | HPGDALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL27687948 | 0.60 | LMNA (0.55) | MAPK8HPGDALDH1A1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820455-A1 | 5H, 10H-IMIDAZO [1,2-a]INDENO [1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031511-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1996-10-10 | — | — | WO | disclosed |