Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552155 | 0.74 | MEN1 (0.48) | HRH3KDM4EHRH1DRD2KCNH2 | |
| SCHEMBL6981478 | 0.72 | KDM4E (0.89) | HRH3KDM4EHRH2HRH1KCNH2 | |
| SCHEMBL5213285 | 0.72 | KDM4E (0.89) | HRH3KDM4EHRH2HRH1KCNH2 | |
| SCHEMBL8557739 | 0.72 | HRH3 (0.48) | HRH3MAOBHTR1AHTR2A | |
| SCHEMBL8558745 | 0.72 | HRH3 (0.46) | HRH3HRH1DRD2HTR1AHTR2A | |
| SCHEMBL491803 | 0.71 | KDM4E (0.92) | HRH3KDM4EHRH2HRH1KCNH2 | |
| SCHEMBL9597499 | 0.71 | HTR1A (0.52) | KDM4EHRH1DRD2KCNH2HTR1A | |
| SCHEMBL8552021 | 0.71 | MEN1 (0.48) | HRH3KDM4EHRH1DRD2KCNH2 | |
| SCHEMBL9664644 | 0.71 | KDM4E (0.68) | HRH3KDM4EHRH2HRH1DRD2 | |
| SCHEMBL5855860 | 0.70 | KDM4E (0.90) | HRH3KDM4EHRH2HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587048-B1 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0587048-A2 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5272148-A | Heteroarenylpiperazines | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-21 | — | — | US | disclosed |