Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556721 | 0.80 | TRPV4 (0.44) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8558579 | 0.78 | KMT2A (0.48) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8561960 | 0.78 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8557444 | 0.75 | MEN1 (0.65) | ALDH1A1KMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8560928 | 0.74 | KMT2A (0.39) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8557533 | 0.69 | NPC1 (0.46) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9125026 | 0.69 | RORC (0.38) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8556724 | 0.66 | ALDH1A1 (0.42) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16607218 | 0.65 | SMN1; SMN2 (0.60) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8558581 | 0.63 | KMT2A (0.49) | ALDH1A1KMT2ARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |