Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CCKAR | P32238 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PLTP | P55058 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560930 | 0.91 | KMT2A (0.41) | KMT2AMEN1CCKARTRPV4MAPT | |
| SCHEMBL8558589 | 0.82 | MEN1 (0.46) | KMT2AMEN1CCKARTRPV4MAPT | |
| SCHEMBL8558579 | 0.81 | KMT2A (0.48) | KMT2AMEN1CCKARALDH1A1HSD17B10 | |
| SCHEMBL8556721 | 0.80 | TRPV4 (0.44) | KMT2AMEN1TRPV4MAPTALDH1A1 | |
| SCHEMBL8557539 | 0.77 | TRPV4 (0.46) | KMT2ATRPV4MAPTALDH1A1HSD17B10 | |
| SCHEMBL9125033 | 0.77 | TRPV4 (0.41) | KMT2AMEN1CCKARTRPV4MAPT | |
| SCHEMBL8896197 | 0.72 | KMT2A (0.54) | KMT2AMEN1CCKARMAPTALDH1A1 | |
| SCHEMBL8560928 | 0.72 | KMT2A (0.39) | KMT2AMEN1CCKARALDH1A1TSHR | |
| SCHEMBL8560935 | 0.72 | ALDH1A1 (0.40) | KMT2AMEN1CCKARTRPV4MAPT | |
| SCHEMBL7684903 | 0.71 | KMT2A (0.42) | KMT2AMEN1CCKARTRPV4PLTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |