Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812094 | 0.88 | ALDH1A1 (0.40) | ACEALDH1A1SMN1; SMN2 | |
| SCHEMBL8552490 | 0.86 | ALDH1A1 (0.42) | ACEALDH1A1POLBCYP2C9 | |
| SCHEMBL8557349 | 0.86 | L3MBTL1 (0.40) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8550015 | 0.84 | ACE (0.38) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8551020 | 0.82 | ACE (0.43) | ACEALDH1A1CYP1A2POLBCYP2C9 | |
| SCHEMBL8552273 | 0.79 | ACE (0.37) | ACEALDH1A1 | |
| SCHEMBL27484036 | 0.77 | ACE (0.40) | ACEALDH1A1 | |
| SCHEMBL8551199 | 0.77 | ALDH1A1 (0.43) | ACEALDH1A1POLBCYP2C9 | |
| SCHEMBL8554773 | 0.75 | ALDH1A1 (0.54) | ACEALDH1A1POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL8595742 | 0.75 | KMT2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |