Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 4/20 | 0.71 |
| ▸ | HTR1A | P08908 | 7/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.65 |
| ▸ | HTR7 | P34969 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557344 | 0.93 | HTR1A (0.76) | MPOHTR1ASLC6A4HTR7KCNH2 | |
| SCHEMBL8557097 | 0.92 | HTR1A (0.70) | MPOHTR1ASLC6A4HTR7KCNH2 | |
| SCHEMBL8558891 | 0.88 | ADRA1D (0.71) | MPOHTR1ASLC6A4HTR7KCNH2 | |
| SCHEMBL8558619 | 0.87 | HTR1A (0.62) | MPOHTR1ASLC6A4HTR7KCNH2 | |
| SCHEMBL7529023 | 0.86 | HTR1A (0.64) | HTR1ASLC6A4HTR7KCNH2OPRM1 | |
| SCHEMBL28937168 | 0.86 | HTR1A (0.73) | HTR1ASLC6A4HTR7KCNH2OPRM1 | |
| SCHEMBL29535031 | 0.86 | HTR1A (0.73) | HTR1ASLC6A4HTR7KCNH2OPRM1 | |
| SCHEMBL8877428 | 0.85 | OPRM1 (0.67) | HTR1ASLC6A4HTR7OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL9030489 | 0.85 | HTR1A (0.63) | HTR1ASLC6A4HTR7KCNH2OPRM1 | |
| SCHEMBL29534956 | 0.85 | HTR1A (0.58) | MPOHTR1ASLC6A4HTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047385-C | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1999-12-15 | — | — | CN | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |