Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.71 |
| ▸ | HTR1A | P08908 | 6/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | HTR7 | P34969 | 2/20 | 0.71 |
| ▸ | MPO | P05164 | 4/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557344 | 0.95 | HTR1A (0.76) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL8557097 | 0.91 | HTR1A (0.70) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL8557700 | 0.88 | MPO (0.71) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL8554029 | 0.85 | HTR1A (0.70) | HTR1ASLC6A4KCNH2HTR7MPO | |
| SCHEMBL8877539 | 0.83 | ADRA1D (0.79) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL8560715 | 0.83 | HTR7 (0.64) | HTR1ASLC6A4KCNH2HTR7MPO | |
| SCHEMBL8871262 | 0.82 | HTR1A (0.67) | HTR1ASLC6A4KCNH2HTR7MPO | |
| Hydrochloric Acid SCHEMBL7823788 | 0.82 | ADRA1D (1.00) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL7256770 | 0.82 | ADRA1D (0.77) | ADRA1DHTR1ASLC6A4KCNH2HTR7 | |
| SCHEMBL25344822 | 0.82 | HTR1A (0.66) | ADRA1DHTR1ASLC6A4HTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |