Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | HTR7 | P34969 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 4/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554029 | 0.94 | HTR1A (0.70) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL9231794 | 0.90 | HTR2A (0.57) | HTR1AKCNH2SLC6A4HTR6 | |
| SCHEMBL8557700 | 0.87 | MPO (0.71) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8557211 | 0.84 | KMT2A (0.52) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8871656 | 0.83 | MPO (0.59) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8557474 | 0.82 | HSD11B1 (0.48) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8557344 | 0.81 | HTR1A (0.76) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8557097 | 0.80 | HTR1A (0.70) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL27319887 | 0.79 | OPRM1 (0.45) | HTR1AHTR7KCNH2SLC6A4HTR6 | |
| SCHEMBL8878576 | 0.79 | SLC6A4 (0.55) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |