Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.37 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555983 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPTSCN9ALMNASLC40A1 | |
| SCHEMBL8560513 | 0.88 | MAPT (0.49) | ALDH1A1MAPTLMNASLC40A1GAA | |
| SCHEMBL8555122 | 0.87 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNASLC40A1TSHR | |
| SCHEMBL8556679 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTSCN9ALMNASLC40A1 | |
| SCHEMBL8557951 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTSCN9ALMNASLC40A1 | |
| SCHEMBL8559481 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPTSCN9ALMNASLC40A1 | |
| SCHEMBL8559666 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASLC40A1GAA | |
| SCHEMBL8556318 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNASLC40A1GGT1 | |
| SCHEMBL8558287 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNASLC40A1TSHR | |
| SCHEMBL8560974 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MAPTSCN9ASLC40A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |