Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561097 | 0.85 | AVPR2 (0.52) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8557743 | 0.83 | AVPR2 (0.64) | AVPR2AVPR1AACHE | |
| SCHEMBL8557503 | 0.82 | ACHE (0.58) | NPC1RAB9ASMN1; SMN2AVPR2AVPR1A | |
| SCHEMBL8563019 | 0.82 | AVPR2 (0.59) | NAMPTAVPR2AVPR1AACHE | |
| SCHEMBL8558857 | 0.82 | HPGD (0.57) | NAMPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8560873 | 0.81 | ACHE (0.60) | NAMPTRAB9AAVPR2AVPR1AACHE | |
| SCHEMBL8563565 | 0.81 | NAMPT (0.50) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8559349 | 0.81 | AVPR2 (0.60) | AVPR2AVPR1AACHE | |
| SCHEMBL8556252 | 0.80 | NAMPT (0.63) | NAMPTNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8558993 | 0.79 | AVPR2 (0.65) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |