Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556252 | 0.87 | NAMPT (0.63) | NAMPTSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL8559546 | 0.87 | AVPR2 (0.55) | HDAC1HDAC8HDAC6ALDH1A1KMT2A | |
| SCHEMBL8557607 | 0.85 | NPC1 (0.50) | RAB9AMAPTALDH1A1NPC1AVPR2 | |
| SCHEMBL8561097 | 0.83 | AVPR2 (0.52) | NAMPTHDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL8558857 | 0.82 | HPGD (0.57) | NAMPTSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL8561645 | 0.81 | AVPR2 (0.58) | RAB9AKDM4ENPC1AVPR2AVPR1A | |
| SCHEMBL8558377 | 0.81 | NAMPT (0.54) | NAMPTSMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL8562633 | 0.78 | AVPR2 (0.55) | SMN1; SMN2RAB9ANPC1AVPR2AVPR1A | |
| SCHEMBL8563019 | 0.78 | AVPR2 (0.59) | NAMPTAVPR2AVPR1A | |
| SCHEMBL8562828 | 0.77 | AVPR2 (0.49) | SMN1; SMN2RAB9AMAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |