Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.38 |
| ▸ | RXRB | P28702 | 3/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555996 | 0.92 | RXRA (0.43) | GAARXRANR4A2RXRBRXRG | |
| SCHEMBL8555127 | 0.88 | NPC1 (0.41) | RXRANR4A2RXRBRXRGALDH1A1 | |
| SCHEMBL8556137 | 0.88 | NR4A2 (0.47) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL8561919 | 0.86 | NR4A2 (0.41) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL8555570 | 0.86 | POLB (0.43) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL7502967 | 0.84 | PTGS2 (0.51) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL7500441 | 0.84 | PTGS2 (0.51) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL8559035 | 0.83 | GRM5 (0.41) | RXRANR4A2RXRBRXRGALOX5AP | |
| SCHEMBL8557612 | 0.81 | RXRA (0.43) | RXRANR4A2RXRBRXRGHPGD | |
| SCHEMBL8554236 | 0.80 | PPARD (0.42) | RXRANR4A2RXRBRXRGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |