Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674633 | 0.79 | LMNA (0.52) | MAPTLMNAGAAALDH1A1TSHR | |
| SCHEMBL8555816 | 0.78 | SIGMAR1 (0.56) | GAAALDH1A1TSHRRAB9ANPC1 | |
| SCHEMBL8555604 | 0.78 | MAPT (0.65) | MAPTLMNAGAAALDH1A1TSHR | |
| SCHEMBL8489945 | 0.77 | PLD1 (0.53) | MAPTLMNAALDH1A1TSHRHPGD | |
| SCHEMBL8555562 | 0.77 | DRD4 (0.54) | MAPTLMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4455153 | 0.76 | MAPT (1.00) | MAPTLMNAGAAALDH1A1TSHR | |
| SCHEMBL8559854 | 0.76 | HRH1 (0.37) | MAPTALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL8555321 | 0.75 | HRH4 (0.42) | MAPTALDH1A1HSD17B10HTR3A | |
| SCHEMBL8671225 | 0.75 | POLB (0.44) | LMNAGAAALDH1A1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7716603 | 0.75 | MAPT (0.96) | MAPTLMNAGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-A1 | PROTON PUMP INHIBITOR | APOTEX INC. (CA) | 1998-12-16 | — | — | EP | claimed |
| WO-1997031923-A1 | PROTON PUMP INHIBITOR | APOTEX INC. (CA) | 1997-09-04 | — | — | WO | claimed |