Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CCKAR | P32238 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560928 | 0.90 | KMT2A (0.39) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8558581 | 0.81 | KMT2A (0.49) | KMT2AMEN1CCKARL3MBTL1ALDH1A1 | |
| SCHEMBL8556719 | 0.78 | GRM5 (0.44) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL8558589 | 0.76 | MEN1 (0.46) | KMT2AMEN1CCKARL3MBTL1ALDH1A1 | |
| SCHEMBL9125026 | 0.76 | RORC (0.38) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8557533 | 0.75 | NPC1 (0.46) | KMT2ACCKARL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL8560930 | 0.73 | KMT2A (0.41) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL7688738 | 0.70 | MEN1 (0.46) | KMT2AMEN1CCKARF10CNR2 | |
| SCHEMBL8896197 | 0.70 | KMT2A (0.54) | KMT2AMEN1CCKARL3MBTL1ALDH1A1 | |
| SCHEMBL9125033 | 0.68 | TRPV4 (0.41) | KMT2AMEN1CCKARALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |