Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | XIAP | P98170 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558579 | 0.90 | KMT2A (0.48) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8560930 | 0.82 | KMT2A (0.41) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL9125026 | 0.81 | RORC (0.38) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8560935 | 0.78 | ALDH1A1 (0.40) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8556719 | 0.74 | GRM5 (0.44) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL9125033 | 0.73 | TRPV4 (0.41) | KMT2AMEN1CCKARALDH1A1TSHR | |
| SCHEMBL8558581 | 0.72 | KMT2A (0.49) | KMT2AMEN1CCKARALDH1A1RAB9A | |
| SCHEMBL8557533 | 0.72 | NPC1 (0.46) | KMT2ACCKARALDH1A1RAB9ANPC1 | |
| SCHEMBL3958982 | 0.70 | CCR2 (0.56) | KMT2AMEN1ALDH1A1TSHRKDM4E | |
| SCHEMBL19410240 | 0.68 | KMT2A (0.52) | KMT2AMEN1ALDH1A1SMN1; SMN2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |