Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.48 |
| ▸ | RXRB | P28702 | 15/20 | 0.48 |
| ▸ | RXRG | P48443 | 14/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 5/20 | 0.42 |
| ▸ | RARG | P13631 | 5/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558866 | 0.84 | RXRA (0.48) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8555859 | 0.80 | RXRA (0.44) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8560346 | 0.77 | RXRA (0.46) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8093051 | 0.75 | RXRA (0.64) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8556010 | 0.74 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8102921 | 0.72 | RXRA (0.51) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8102771 | 0.72 | ALDH1A1 (0.51) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8103047 | 0.72 | RXRA (0.47) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8556269 | 0.71 | CYP26B1 (0.46) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL9446455 | 0.71 | RXRA (0.52) | RXRARXRBRXRGCYP26B1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |