Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.70 |
| ▸ | MMP13 | P45452 | 10/20 | 0.70 |
| ▸ | MMP9 | P14780 | 9/20 | 0.58 |
| ▸ | PDE4A | P27815 | 8/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.58 |
| ▸ | MMP2 | P08253 | 7/20 | 0.58 |
| ▸ | MMP3 | P08254 | 7/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | MMP16 | P51512 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928607 | 0.83 | MMP1 (1.00) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL8558984 | 0.79 | MMP13 (0.55) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL8713229 | 0.78 | MMP1 (0.58) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL6934594 | 0.77 | MMP1 (0.73) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL7388627 | 0.74 | PDE4A (0.44) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL7373322 | 0.74 | MMP9 (0.57) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL7373320 | 0.74 | MMP9 (0.57) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL6931491 | 0.73 | MMP1 (1.00) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL6823156 | 0.73 | MMP2 (1.00) | MMP1MMP13MMP9PDE4APDE4B | |
| SCHEMBL6929276 | 0.72 | MMP1 (0.70) | MMP1MMP13MMP9PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804593-A | FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. | PHARMACIA & UPJOHN COMPANY (US) | 1998-09-08 | — | — | US | disclosed |