Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | RXRB | P28702 | 4/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560020 | 0.92 | RXRA (0.39) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL8559262 | 0.92 | NR4A2 (0.40) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL8560006 | 0.91 | RXRA (0.48) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL8558256 | 0.91 | MAOB (0.41) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL8558565 | 0.88 | PTGS2 (0.44) | RXRARXRBRXRGMAOBPTGS1 | |
| SCHEMBL8560188 | 0.88 | PTGS2 (0.47) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL8559238 | 0.86 | PTGS2 (0.42) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL7500949 | 0.86 | RXRA (0.45) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL8555759 | 0.86 | PTGS2 (0.39) | RXRARXRBRXRGMAOBNR4A2 | |
| SCHEMBL8560576 | 0.86 | RXRA (0.46) | RXRARXRBRXRGNR4A2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |