Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561125 | 0.93 | PTGS2 (0.47) | PTGS2PTGS1ADORA2AADORA1RXRA | |
| SCHEMBL8555759 | 0.93 | PTGS2 (0.39) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL8559432 | 0.92 | MAPK1 (0.40) | ADORA1RXRASCN9AMAPT | |
| SCHEMBL8560736 | 0.89 | PTGS2 (0.47) | PTGS2PTGS1RXRASCN9AMAPT | |
| SCHEMBL8555918 | 0.89 | RXRA (0.38) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL8560006 | 0.88 | RXRA (0.48) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL8559701 | 0.88 | RXRA (0.39) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL7505718 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1ADORA2AADORA1RXRA | |
| SCHEMBL8560020 | 0.86 | RXRA (0.39) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL8559470 | 0.85 | RXRA (0.41) | PTGS2PTGS1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |